The last few decades have seen an increase in the research on human memory. Human brain is an extremely complicated and a unique device among the living beings. The topics covered are Plasticity, Unprecedented Identities and Coolness in correspondence to trauma, which are depicted in Alex Michaelides’ novel ‘The Silent Patient’. The characters in the novel go through various psychological conditions. Literature is an important field of introspection on memory studies. A fiction is an amalgamation of realities and possibilities. The articulation of absence in a fiction makes it a cognitive medium, for the interplay of Memory Studies and Medical Humanities. A rigid understanding of remembering and forgetting is achieved through a critical study.